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Studies show that oligomenorrhoeic PMOS patients have elevated kisspeptin pulse frequency but a broken temporal coupling between kisspeptin and LH pulses — meaning kisspeptin is firing, but it is not translating into coordinated ovulatory signalling

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To test the hypothesis that increased IGF-1 levels may mediate the effects of anti-miR-483-3p, we added IGF-1-neutralizing antibody (anti-IGF-1) to the anti-miR-483-3p-transfected dNK cell culture to neutralize the expression of IGF-1